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2003 3
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91 results

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Page 1
m6A RNA methylation regulates the transcription factors JUN and JUNB in TGF-beta-induced epithelial-mesenchymal transition of lung cancer cells.
Suphakhong K, Terashima M, Wanna-Udom S, Takatsuka R, Ishimura A, Takino T, Suzuki T. Suphakhong K, et al. J Biol Chem. 2022 Nov;298(11):102554. doi: 10.1016/j.jbc.2022.102554. Epub 2022 Sep 29. J Biol Chem. 2022. PMID: 36183833 Free PMC article.
Furthermore, we discovered that different m6A reader proteins interacted with JUN and JUNB mRNA and controlled m6A-dependent expression of JUN protein and JUNB mRNA. These results demonstrate that the different modes of m6A-mediated regulation of JUN and JUNB …
Furthermore, we discovered that different m6A reader proteins interacted with JUN and JUNB mRNA and controlled m6A-dependent expressi …
Stratification of radiosensitive brain metastases based on an actionable S100A9/RAGE resistance mechanism.
Monteiro C, Miarka L, Perea-García M, Priego N, García-Gómez P, Álvaro-Espinosa L, de Pablos-Aragoneses A, Yebra N, Retana D, Baena P, Fustero-Torre C, Graña-Castro O, Troulé K, Caleiras E, Tezanos P, Muela P, Cintado E, Trejo JL, Sepúlveda JM, González-León P, Jiménez-Roldán L, Moreno LM, Esteban O, Pérez-Núñez Á, Hernández-Lain A, Mazarico Gallego J, Ferrer I, Suárez R, Garrido-Martín EM, Paz-Ares L, Dalmasso C, Cohen-Jonathan Moyal E, Siegfried A, Hegarty A, Keelan S, Varešlija D, Young LS, Mohme M, Goy Y, Wikman H, Fernández-Alén J, Blasco G, Alcázar L, Cabañuz C, Grivennikov SI, Ianus A, Shemesh N, Faria CC, Lee R, Lorigan P, Le Rhun E, Weller M, Soffietti R, Bertero L, Ricardi U, Bosch-Barrera J, Sais E, Teixidor E, Hernández-Martínez A, Calvo A, Aristu J, Martin SM, Gonzalez A, Adler O, Erez N; RENACER; Valiente M. Monteiro C, et al. Nat Med. 2022 Apr;28(4):752-765. doi: 10.1038/s41591-022-01749-8. Epub 2022 Apr 11. Nat Med. 2022. PMID: 35411077 Free PMC article.
Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RAGE-NF-kappaB-JunB pathway in brain metastases as a potential mediator of resistance in this organ. Targeting this pathway genetically …
Through an unbiased analysis of experimental in vivo models of brain metastasis resistant to WBRT, we identified activation of the S100A9-RA …
CRISPR screening identifies the deubiquitylase ATXN3 as a PD-L1-positive regulator for tumor immune evasion.
Wang S, Iyer R, Han X, Wei J, Li N, Cheng Y, Zhou Y, Gao Q, Zhang L, Yan M, Sun Z, Fang D. Wang S, et al. J Clin Invest. 2023 Dec 1;133(23):e167728. doi: 10.1172/JCI167728. J Clin Invest. 2023. PMID: 38038129 Free PMC article.
Moreover, ATXN3 functioned as a deubiquitinase of the AP-1 transcription factor JunB, indicating that ATNX3 promotes PD-L1 expression through multiple pathways. ...Furthermore, tumoral ATXN3 suppression improved the preclinical efficacy of checkpoint blockade antitumor imm …
Moreover, ATXN3 functioned as a deubiquitinase of the AP-1 transcription factor JunB, indicating that ATNX3 promotes PD-L1 expression …
Phenotypic Characterization of Circulating Tumor Cells Isolated from Non-Small and Small Cell Lung Cancer Patients.
Roumeliotou A, Pantazaka E, Xagara A, Dimitrakopoulos FI, Koutras A, Christopoulou A, Kourelis T, Aljarba NH, Alkahtani S, Koinis F, Kotsakis A, Kallergi G. Roumeliotou A, et al. Cancers (Basel). 2022 Dec 28;15(1):171. doi: 10.3390/cancers15010171. Cancers (Basel). 2022. PMID: 36612166 Free PMC article.
In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients and investigated whether these proteins have prognostic clinical relevance. ...Both JUNB and CXCR4 were expressed in the vast majorit …
In the present study, we evaluated the expression of JUNB and CXCR4 in circulating tumor cells (CTCs) of lung cancer patients …
AP-1 Contributes to Chromatin Accessibility to Promote Sarcomere Disassembly and Cardiomyocyte Protrusion During Zebrafish Heart Regeneration.
Beisaw A, Kuenne C, Guenther S, Dallmann J, Wu CC, Bentsen M, Looso M, Stainier DYR. Beisaw A, et al. Circ Res. 2020 Jun 5;126(12):1760-1778. doi: 10.1161/CIRCRESAHA.119.316167. Epub 2020 Apr 21. Circ Res. 2020. PMID: 32312172 Free PMC article.
We further show that overexpression of the AP-1 family members Junb and Fosl1 can promote changes in mammalian cardiomyocyte behavior in vitro. ...
We further show that overexpression of the AP-1 family members Junb and Fosl1 can promote changes in mammalian cardiomyocyte behavior …
JunB promotes cell invasion, migration and distant metastasis of head and neck squamous cell carcinoma.
Hyakusoku H, Sano D, Takahashi H, Hatano T, Isono Y, Shimada S, Ito Y, Myers JN, Oridate N. Hyakusoku H, et al. J Exp Clin Cancer Res. 2016 Jan 12;35:6. doi: 10.1186/s13046-016-0284-4. J Exp Clin Cancer Res. 2016. PMID: 26754630 Free PMC article.
The efficacy of knockout of JunB was also examined using an experimental lung metastatic mouse model of HNSCC. ...In addition, the knockout of JunB in metastatic HNSCC cells significantly repressed the incidence of lung metastases and prolonged the sur …
The efficacy of knockout of JunB was also examined using an experimental lung metastatic mouse model of HNSCC. ...In addition, …
Role and regulation of activator protein-1 in toxicant-induced responses of the lung.
Reddy SP, Mossman BT. Reddy SP, et al. Am J Physiol Lung Cell Mol Physiol. 2002 Dec;283(6):L1161-78. doi: 10.1152/ajplung.00140.2002. Am J Physiol Lung Cell Mol Physiol. 2002. PMID: 12424143 Free article. Review.
Gene disruption studies indicate that the AP-1 family members c-jun, junB, and fra1 are essential for embryonic development, whereas junD, c-fos, and fosB are required for normal postnatal growth. ...This implies that, although they are required for normal cellular process …
Gene disruption studies indicate that the AP-1 family members c-jun, junB, and fra1 are essential for embryonic development, whereas …
ALK gene aberrations and the JUN/JUNB/PDGFR axis in metastatic NSCLC.
Berghoff AS, Birner P, Streubel B, Kenner L, Preusser M. Berghoff AS, et al. APMIS. 2014 Sep;122(9):867-72. doi: 10.1111/apm.12249. Epub 2014 Apr 3. APMIS. 2014. PMID: 24750504
Here, we investigated the ALK/JUN/JUNB/transcription factor Jun C (JUNC)/PDGFR axis in metastatic NSCLC with regard to ALK aberrations. ...We did not find a statistically significant difference in expression of PDGFRA, PDGFRB, JUNB or JUNC in tumor samples with norm …
Here, we investigated the ALK/JUN/JUNB/transcription factor Jun C (JUNC)/PDGFR axis in metastatic NSCLC with regard to ALK aberration …
91 results